Abstract
Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry*
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Amides / pharmacology*
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Animals
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Blood Glucose / metabolism
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / enzymology*
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Dipeptidyl Peptidase 4 / metabolism*
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Dipeptidyl-Peptidase IV Inhibitors / chemical synthesis
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Dipeptidyl-Peptidase IV Inhibitors / chemistry*
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Dipeptidyl-Peptidase IV Inhibitors / pharmacology*
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Dogs
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Glucose Tolerance Test
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Humans
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Mice
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Mice, Inbred C57BL
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Models, Molecular
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Piperazines / chemical synthesis
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Piperazines / chemistry
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Piperazines / pharmacology
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Rats
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Rats, Sprague-Dawley
Substances
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Amides
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Blood Glucose
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Dipeptidyl-Peptidase IV Inhibitors
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Piperazines
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Dipeptidyl Peptidase 4